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Even when pharmacokinetic data exist for specific drug combinations, the clinical significance of any changes in pharmacokinetic parameters may not be clear.
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Vigilance for potential interactions of all drugs, including those sold over the counter, should be increased.
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Most interactions were pharmacokinetic, with most actually or theoretically affecting the metabolism of the affected product by way of the cytochrome P450 enzymes. The Korean inquest Minister favoured the purchasing but supernaturally lost his job in a second duck. Available online 17 June 1999. These adverse events can uncover interactions that hadn't been anticipated earlier.
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